[2] River Plate Asunción 2-1 Peñarol [1] 2021-05-18 22:15
Stadium: Estadio Defensores del Chaco Round: 5
Referee: Fernando Echenique Home Manager: Celso Rafael Ayala Gavilan Away Manager: Mauricio Larriera
Head to Head
| Copa Sudamericana | 2021/05/07 00:30 | Peñarol v River Plate Asunción | L | 3-0 |
Home History
| Paraguay División Profesional | 2021/05/16 21:45 | River Plate Asunción v Cerro Porteño | D | 1-1 |
| Copa Sudamericana | 2021/05/14 00:30 | River Plate Asunción v Sport Huancayo | W | 2-1 |
| Paraguay División Profesional | 2021/05/10 00:00 | Guairena FC v River Plate Asunción | D | 0-0 |
| Copa Sudamericana | 2021/05/07 00:30 | Peñarol v River Plate Asunción | L | 3-0 |
| Paraguay División Profesional | 2021/05/03 23:00 | River Plate Asunción v Libertad Asunción | L | 1-3 |
| Copa Sudamericana | 2021/04/29 22:15 | Sport Huancayo v River Plate Asunción | W | 1-2 |
| Paraguay División Profesional | 2021/04/26 22:15 | Sportivo Luqueño v River Plate Asunción | D | 2-2 |
| Copa Sudamericana | 2021/04/23 00:30 | River Plate Asunción v Corinthians | D | 0-0 |
Away History
| Copa Sudamericana | 2021/05/14 00:30 | Peñarol v Corinthians | W | 4-0 |
| Copa Sudamericana | 2021/05/07 00:30 | Peñarol v River Plate Asunción | W | 3-0 |
| Copa Sudamericana | 2021/04/29 22:15 | Corinthians v Peñarol | W | 0-2 |
| Copa Sudamericana | 2021/04/23 00:30 | Peñarol v Sport Huancayo | W | 5-1 |
| Copa Sudamericana | 2021/04/14 00:30 | Peñarol v Cerro Largo | W | 4-1 |
| Copa Sudamericana | 2021/04/07 00:30 | Cerro Largo v Peñarol | D | 2-2 |
| Uruguay Clausura | 2021/03/30 00:15 | Peñarol v Atlético Fénix Montevideo | W | 3-1 |
| Uruguay Clausura | 2021/03/25 19:00 | Club Atlético Progreso v Peñarol | W | 0-2 |