[10] River Plate Asunción 1-1 Cerro Porteño [3] 2021-05-16 21:45
Stadium: Estadio River Plate Round: 16
Referee: Eber Aquino Home Manager: Celso Rafael Ayala Gavilan Away Manager: Francisco Arce
Head to Head
| Paraguay División Profesional | 2021/03/09 23:45 | Cerro Porteño v River Plate Asunción | L | 3-0 |
| Paraguay División Profesional | 2020/11/20 21:30 | River Plate Asunción v Cerro Porteño | L | 1-2 |
| Paraguay División Profesional | 2020/09/26 23:30 | Cerro Porteño v River Plate Asunción | L | 3-1 |
| Paraguay División Profesional | 2020/07/25 22:30 | River Plate Asunción v Cerro Porteño | L | 0-2 |
| Paraguay División Profesional | 2019/11/27 23:00 | River Plate Asunción v Cerro Porteño | L | 1-2 |
| Paraguay División Profesional | 2019/09/02 23:00 | Cerro Porteño v River Plate Asunción | L | 2-0 |
| Paraguay División Profesional | 2019/04/13 23:30 | River Plate Asunción v Cerro Porteño | L | 1-5 |
| Paraguay División Profesional | 2019/02/10 23:30 | Cerro Porteño v River Plate Asunción | L | 3-1 |
Home History
| Copa Sudamericana | 2021/05/14 00:30 | River Plate Asunción v Sport Huancayo | W | 2-1 |
| Paraguay División Profesional | 2021/05/10 00:00 | Guairena FC v River Plate Asunción | D | 0-0 |
| Copa Sudamericana | 2021/05/07 00:30 | Peñarol v River Plate Asunción | L | 3-0 |
| Paraguay División Profesional | 2021/05/03 23:00 | River Plate Asunción v Libertad Asunción | L | 1-3 |
| Copa Sudamericana | 2021/04/29 22:15 | Sport Huancayo v River Plate Asunción | W | 1-2 |
| Paraguay División Profesional | 2021/04/26 22:15 | Sportivo Luqueño v River Plate Asunción | D | 2-2 |
| Copa Sudamericana | 2021/04/23 00:30 | River Plate Asunción v Corinthians | D | 0-0 |
| Paraguay División Profesional | 2021/04/18 00:00 | River Plate Asunción v Sol de América | L | 0-2 |
Away History
| Copa Libertadores | 2021/05/13 00:00 | Deportivo La Guaira v Cerro Porteño | W | 0-1 |
| Paraguay División Profesional | 2021/05/09 00:00 | Cerro Porteño v Nacional Asunción | D | 2-2 |
| Copa Libertadores | 2021/05/04 22:15 | Atlético Mineiro v Cerro Porteño | L | 4-0 |
| Paraguay División Profesional | 2021/05/02 00:00 | Cerro Porteño v Olimpia Asunción | W | 2-0 |
| Copa Libertadores | 2021/04/28 22:00 | Cerro Porteño v Deportivo La Guaira | D | 0-0 |
| Paraguay División Profesional | 2021/04/25 21:45 | Guairena FC v Cerro Porteño | W | 0-1 |
| Copa Libertadores | 2021/04/22 02:00 | América de Cali v Cerro Porteño | W | 0-2 |
| Paraguay División Profesional | 2021/04/18 21:45 | Cerro Porteño v Libertad Asunción | L | 0-3 |