Stadium: Community School of Naples
Home Manager: Matt McMahon Away Manager: Mark Byington
| NCAAB | 2021/11/23 17:00 | James Madison v Wright State | W | 78-76 |
| NCAAB | 2021/11/22 17:00 | Kent State v James Madison | L | 74-69 |
| NCAAB | 2021/11/20 00:00 | George Mason v James Madison | W | 64-67 |
| NCAAB | 2021/11/17 00:00 | James Madison v Eastern Kentucky | W | 79-78 |
| NCAAB | 2021/11/13 21:00 | Old Dominion v James Madison | W | 53-58 |
| NCAAB | 2021/11/11 00:00 | James Madison v Carlow (Pa) Celtics | W | 135-40 |
| NCAAB | 2021/03/07 19:30 | Elon v James Madison | L | 72-71 |
| NCAAB | 2021/02/26 21:00 | Drexel v James Madison | L | 84-78 |
| NCAAB | 2021/11/23 19:30 | Murray State v Long Beach State | W | 80-43 |
| NCAAB | 2021/11/22 22:30 | East Tenn St v Murray State | L | 66-58 |
| NCAAB | 2021/11/17 01:00 | Murray State v Illinois St | W | 77-65 |
| NCAAB | 2021/11/14 01:00 | Bellarmine v Murray State | W | 59-78 |
| NCAAB | 2021/11/10 01:00 | Murray State v Cumberland Phoenix | W | 109-77 |
| NCAAB | 2021/03/05 01:00 | Murray State v Jacksonville St | L | 65-68 |
| NCAAB | 2021/02/28 02:00 | Murray State v Tennessee Tech | L | 61-71 |
| NCAAB | 2021/02/26 01:30 | Murray State v Jacksonville St | L | 74-87 |